The Function of Mitochondria

If you did biology at school you may remember being told about mitochondria.  The function of mitochondria is vital to our health and mitochondrial dysfunction heralds the onset of serious health problems.

mitochondrionWhat are mitochondria exactly

Here is a diagram of one mitochrondrion and as you can see, there’s a lot going on inside this tiny ‘organelle’.  They  reside in our cells (except red blood cells) in their hundreds and often thousands .  A liver cell, for example, can have upwards of 2000 mitrochondria.

Organelle?

In biological terms, an organelle is a separate structure residing inside a cell which corresponds to an organ residing within our body.  The suffix ‘elle’ meaning diminutive.

An immense subject

Now I’m not going to go into the ins and outs of mitochondria because the subject is immense and these tiny organelles have a vast array of roles to play.  Some researchers and medical professionals specialise in just mitochondrial function; this area of medical science is a branch of study on its own!

Suffice to say, it is thought by many eminent researchers that the health of the mitochondria is the answer to the majority of our diseases and mitochondrial dysfunction,  will be exhibited at the baseline of all conditions.

Energy production

Have a look at this short video.  It is actually advertising a good book on Magnesium (Mg) and heart disease, by cardiologist Dr Dennis Goodman MD,  but it also explains simply, how Mg is vital to produce ATP (adenosine triphosphate) the energy source of our bodies, which resides within the mighty mitochondria.

Mg-ATP?

It’s important to note that when researchers and scientists talk about ATP they are nearly always referring to the activated version which is when it is magnesium bound as Mg-ATP.  For convenience, the Mg has been dropped in most instances, which only serves to hide the role of magnesium in the process of producing energy.  This abbreviated notation of ATP may be one of the reasons why the importance of Mg is overlooked in so many instances of disease, particularly with our biggest killer cardiovascular diseases of which Coronary Artery Disease (Ischemic Heart Disease) is the deadliest disease in the world.

Mitochondria’s most important role

heartSo, one of the main purposes of these organelles is to generate energy for the cell it resides in.  Mitochondria converts the energy of glucose and oxygen into Mg-ATP our energy currency which powers the functions of the cell.  To run our body’s cells, copious amounts of energy are needed, but not all cells have the same amount of mitochondria.  Heart muscle cells are purported to have up to 5,000 mitochrondria within them.  You may think our other main muscles likebiceps the biceps would have a similar amount but they have about 200 per cell.  Therefore, the number of mitochondria in a cell is proportional to the energy demand of that cell.  The heart has to beat continuously over our lifetime without stopping.  The biceps are used spasmodically in comparison, hence the lesser amount of mitochondria.  Understanding mitochondrial function is critical to the understanding of intracellular health.

No energy, no life

As you can imagine, without efficient functioning of mitochondria and with a lack of enough energy needed to drive the cell, problems will ensue.  Our organs need much energy to be able to function properly.  Those organs that need the most are:

  • The Brain
  • The Heart
  • The Lungs
  • The Liver
  • The Kidneys
  • The Muscles
  • The Digestive System

Without any one of these organs working properly, our health is seriously compromised.  Can you think of any part of our body that does not need some energy to work effectively?  Even when we’re asleep, the body is hard at work.

ferrariFerrari or Reliant Robin!

We are the car and the mitochondria provides the fuel.  WithoutReliant it, we’re not going anywhere fast.  Just as a car runs on petrol/diesel, so our bodies run on Mg-ATP.  A good supply of healthy mitochondria within our cells is the difference between being a Ferrari or a Reliant Robin!  When a car runs out of fuel, it coughs and splutters and slowly comes to a halt, this is an analogy of what happens to the body.  When the cells start to deteriorate and die, the body and its organs become starved of energy.  Without healthy intervention, the outcome is either a slow decline or a sudden death.

Doctors & mitochondria

Did you know that many of our doctors are not taught about mitochondria during their medical training.  This most important tiny structure working at a cellular level is probably not even considered when a doctor tries to diagnose your illness.  This to me is incredulous because it is at this level that things start to go wrong in our bodies.  This is often the nub of our diseases.  Our cells are the building blocks of our body.  If they are not healthy, we will suffer a multitude of problems and if mitochondrial dysfunction is not addressed, the body will slowly deteriorate and die before its time.

Isn’t good health common sense?

babies and drugsSo what can we do?  What we need to do with our health is to use some common sense!  We were born with a certain amount and balance of nutrients, vitamins and minerals.  The body was not born with pharmaceutical drugs inside it.  Yes, drugs do have there place when all else fails but generally, for most degenerating conditions such as heart disease, autoimmune conditions like parkinson’s and alzheimer’s, illnesses such as diabetes, cancer and stroke, complaints such as ADHD, ADD and OCD, all these diseases start at the cellular level which means it starts with a dysfunction within our cells.

Junk food and toxins

You’ve heard the saying “rubbish in, rubbish out”, well that applies to our bodies too.  Apart from the junk food, excess sugars and sodas we ingest, we are bombarded with toxins and pollutants on a daily basis.  We’re breathing in polluted air and eating polluted products.

To fight this onslaught on your body, you have to be proactive.  Make sure you and your family keep off the junk food.  Try and stop consuming sodas and cut back on sugar intake. Buy as much organic food as you can afford and cook you own meals.  At least you will have some idea of what’s in them.   If you have a garden, grow your own veggies!

Mg glassYour 1st line of attack!

As for your cellular health and mitochondria, keep them in good fettle by taking in the best supplements and nutrients.  Remember that ATP in its active form is Mg-ATP.  Mg-ATP cannot be produced without magnesium.   So this is your first line of attack.  Taking magnesium regularly and keeping yourself replete will make all the difference to your energy levels and all the difference to your general health, including your heart and vascular system.

The heart and Mg

Heart muscle cell mitochondria without Mg will induce heart attack.  When a heart attack happens, mitochondria are disrupted and damaged.  So what causes this damage?

Ca crystals in MitoEarly research

Research was done in the 1970s by Dr Burton Silver, Dr Lou Sordahl along with the collaboration of Dr Michael DeBakey’s biochemical group in Houston.  Dr Silver took this amazing transmission electron micrograph (TEM) which showed what happens during a heart attack.  With no Mg, dense Ca and phosphorus crystals form within the mitochondria.  They are like black sharp needles and needless to say, they cause irreversible damage to heart tissue.  This is evidence of mitochondrial dysfunction during a heart event.

Plant mitochrondriaPlant mitochondria

Another study shows a similar micrograph  This was a study in plant mitochondria in 1974 and the abstract states: “This study demonstrates that isolated corn shoot mitochondria will accumulate calcium phosphate crystals in vitro that are comparable to those observed in both in vivo and in vitro animal mitochondria.”  Those of you who are into gardening have probably come across ‘blossom end rot’ particularly in tomato plants which is caused by an excess of Ca causing cell death in the plant.

And with Magnesium

Even more amazing was the discovery with Dr Silver and co’s research, that an administration or infusion of Mg prior to or during a heart attack, would prevent and protect the heart muscle from forming these destructive crystals.  What we now know is that Mg is necessary to control Ca’s entry into and exit out of the cells.  If Mg is deficient, it will allow Ca to stay in the cell causing cell death.

Ca CloseupDeath by Calcium!

When we die, our cells are flooded with Ca which starts the death throws of our body, heralding the start of rigor mortis.  If Ca is allowed to stay in the cell, it will kill it!  Of course Ca is vital to us but it is toxic in excess.  If there was always enough Mg to control it, that would be great.  Our diet just does not have enough Mg to keep Ca in check but the answer is simple.  Make sure you are replete with Mg.  Don’t take Ca supplements or Ca in forms such as antacids.  If your doctor prescribes Ca supplementation, ask why and remind him about balancing with Mg.  Be tactful!  Medics are not usually knowledgable about Mg.  Most of us obtain enough Ca from our food, which is abundant and often fortified in our modern diet.

Be Aware!

Be aware, learn about your health, take your health into your hands.  You know how you feel.  if you’re feeling unwell, fatigued, depressed, anxious, stressed out, make sure you Ches Powerknow about your condition before you see your medic.  You can then work with him to do the best for your problems.  Don’t just leave it to him.  You can’t expect doctors to know all about every condition and disease and he will more likely prescribe a drug which does not get to the core of your complaint and usually adds another burden to your body.  Be proactive and question everything!

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medical termsIn medical terms…

But with respect to medical terms, it means mortality from any disease, infection or medical condition and there simply is no ‘silver bullet’ which will protect you from all- cause mortality…  but there is something that comes close. Continue reading What Is All-Cause Mortality

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David Beckham
David Beckham has TS

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over the counter NexiumNow an ‘over the counter’ drug

If you have been prescribed with a PPI (proton pump inhibitor) drug, no doubt it will be something like Nexium (esomeprazole), Prilosec (omeprazole), Protonix (pantoprazole), Prevacid (lansoprazole) or Zegerid (omeprazole) for example.  But now these drugs can be bought without a prescription, known as an over the counter drug.  This means you can buy them willy nilly and poison yourself even quicker than if you’d gone to the doctor for some. Continue reading Proton Pump Inhibitors Side Effects